Assay Detail
Binding
CHEMBL5628150
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Inhibition of PARP1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.14 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322618 | — | — | 1 | 9.51 |
| CHEMBL3907010 | — | — | 1 | 8.76 |
| CHEMBL2323226 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322618 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3907010 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL2323226 | — | IC50 | = | 3.46 | nM | - |