Assay Detail
Toxicity
CHEMBL5628161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.83 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5632420 | — | — | 1 | 5.39 |
| CHEMBL5633982 | — | — | 1 | 4.76 |
| CHEMBL5631710 | — | — | 1 | 4.76 |
| CHEMBL5631857 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5632420 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5633982 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL5631710 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5631857 | — | IC50 | = | 40000.0 | nM | 4.40 |