Assay Detail
Binding
CHEMBL5628188
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING R232 mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed by washout and measured after 5 hrs by Bright-glo luciferase assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465054 | — | — | 1 | 7.70 |
| CHEMBL5631622 | — | — | 1 | 7.70 |
| CHEMBL5631465 | — | — | 1 | 7.52 |
| CHEMBL5190773 | — | — | 1 | 7.10 |
| CHEMBL4449584 | — | — | 1 | 6.92 |
| CHEMBL5632142 | — | — | 1 | 6.92 |
| CHEMBL5633953 | — | — | 1 | 6.55 |
| CHEMBL5631976 | — | — | 1 | 6.30 |
| CHEMBL5632743 | — | — | 1 | 6.16 |
| CHEMBL5632563 | — | — | 1 | 6.12 |
| CHEMBL5633949 | — | — | 1 | 6.11 |
| CHEMBL5633033 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465054 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5631622 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5631465 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5190773 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4449584 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5632142 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5633953 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5631976 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5632743 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5632563 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5633949 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5633033 | — | EC50 | = | 10790.0 | nM | 4.97 |