Assay Detail
Binding
CHEMBL5628191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING G230A/R293Q mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed by washout and measured after 5 hrs by Bright-glo luciferase assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.67 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465054 | — | — | 1 | 7.40 |
| CHEMBL5631622 | — | — | 1 | 7.10 |
| CHEMBL5631465 | — | — | 1 | 7.00 |
| CHEMBL5632142 | — | — | 1 | 6.89 |
| CHEMBL5633949 | — | — | 1 | 6.68 |
| CHEMBL5190773 | — | — | 1 | 6.64 |
| CHEMBL4449584 | — | — | 1 | 6.58 |
| CHEMBL5632743 | — | — | 1 | 6.54 |
| CHEMBL5633953 | — | — | 1 | 6.41 |
| CHEMBL5633033 | — | — | 1 | 6.41 |
| CHEMBL5632563 | — | — | 1 | 6.40 |
| CHEMBL5631976 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465054 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5631622 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5631465 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5632142 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5633949 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5190773 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4449584 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5632743 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5633953 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5633033 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5632563 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5631976 | — | EC50 | = | 950.0 | nM | 6.02 |