Assay Detail
Binding
CHEMBL5628192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING R293Q mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed by washout and measured after 5 hrs by Bright-glo luciferase assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.83 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465054 | — | — | 1 | 7.30 |
| CHEMBL5631622 | — | — | 1 | 6.34 |
| CHEMBL5190773 | — | — | 1 | 6.00 |
| CHEMBL5631465 | — | — | 1 | 5.98 |
| CHEMBL5633953 | — | — | 1 | 5.82 |
| CHEMBL4449584 | — | — | 1 | 5.69 |
| CHEMBL5632142 | — | — | 1 | 5.53 |
| CHEMBL5632743 | — | — | 1 | 5.38 |
| CHEMBL5632563 | — | — | 1 | 5.18 |
| CHEMBL5631976 | — | — | 1 | 5.06 |
| CHEMBL5633949 | — | — | 1 | - |
| CHEMBL5633033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465054 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5631622 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5190773 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5631465 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5633953 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4449584 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5632142 | — | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5632743 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5632563 | — | EC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL5631976 | — | EC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL5633949 | — | EC50 | > | 45000.0 | nM | - |
| CHEMBL5633033 | — | EC50 | > | 45000.0 | nM | - |