Assay Detail
Binding
CHEMBL5628522
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Inhibition of recombinant HDAC1 (unknown origin) using RHKK-Ac-AMC as substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.43 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.14 |
| CHEMBL5629961 | — | — | 1 | 6.41 |
| CHEMBL5631370 | — | — | 1 | 6.01 |
| CHEMBL5633941 | — | — | 1 | 6.00 |
| CHEMBL5631908 | — | — | 1 | 6.00 |
| CHEMBL5632901 | — | — | 1 | 5.89 |
| CHEMBL5633237 | — | — | 1 | 5.55 |
| CHEMBL5631448 | — | — | 1 | 5.50 |
| CHEMBL5632170 | — | — | 1 | 5.07 |
| CHEMBL5632247 | — | — | 1 | 5.05 |
| CHEMBL5631817 | — | — | 1 | 4.53 |
| CHEMBL5631614 | — | — | 1 | 4.41 |
| CHEMBL5633420 | — | — | 1 | 4.41 |
| CHEMBL5632233 | — | — | 1 | 4.34 |
| CHEMBL5633219 | — | — | 1 | 4.13 |
| CHEMBL5632046 | — | — | 1 | - |
| CHEMBL5631797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5629961 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5631370 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5633941 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5631908 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5632901 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5633237 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5631448 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5632170 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL5632247 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5631817 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL5631614 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL5633420 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL5632233 | — | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL5633219 | — | IC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL5632046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5631797 | — | IC50 | > | 100000.0 | nM | - |