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Assay Detail

CHEMBL5628812

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Functional
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy.
Wang Z, Wu D, Zhao X, Liu C, Jia S, He Q, Huang F, Cheng Z, Lu T, Chen Y, Chen Y, Yang P, Lu S.
Eur J Med Chem (2023) 260 : 115759 -115759
PubMed 37659198 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.01 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4077071 1 8.15
CHEMBL5618643 1 7.04
CHEMBL5632592 1 6.80
CHEMBL5632493 1 6.43
CHEMBL98 VORINOSTAT 4.0 1 6.38
CHEMBL5631737 1 6.31
CHEMBL5632450 1 6.16
CHEMBL5631238 1 6.03
CHEMBL5632762 1 6.00
CHEMBL5631242 1 5.97
CHEMBL5633405 1 5.80
CHEMBL5633679 1 5.73
CHEMBL5631257 1 5.69
CHEMBL5633325 1 5.68
CHEMBL5631818 1 5.43
CHEMBL5633767 1 5.36
CHEMBL5631871 1 5.32
CHEMBL5632212 1 5.30
CHEMBL5632335 1 5.28
CHEMBL5633912 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4077071 IC50 = 7.0 nM 8.15
CHEMBL5618643 IC50 = 92.0 nM 7.04
CHEMBL5632592 IC50 = 157.0 nM 6.80
CHEMBL5632493 IC50 = 367.0 nM 6.43
CHEMBL98 VORINOSTAT IC50 = 421.0 nM 6.38
CHEMBL5631737 IC50 = 487.0 nM 6.31
CHEMBL5632450 IC50 = 698.0 nM 6.16
CHEMBL5631238 IC50 = 934.0 nM 6.03
CHEMBL5632762 IC50 = 989.0 nM 6.00
CHEMBL5631242 IC50 = 1081.0 nM 5.97
CHEMBL5633405 IC50 = 1570.0 nM 5.80
CHEMBL5633679 IC50 = 1860.0 nM 5.73
CHEMBL5631257 IC50 = 2039.0 nM 5.69
CHEMBL5633325 IC50 = 2076.0 nM 5.68
CHEMBL5631818 IC50 = 3713.0 nM 5.43
CHEMBL5633767 IC50 = 4383.0 nM 5.36
CHEMBL5631871 IC50 = 4800.0 nM 5.32
CHEMBL5632212 IC50 = 4996.0 nM 5.30
CHEMBL5632335 IC50 = 5228.0 nM 5.28
CHEMBL5633912 IC50 = 5692.0 nM 5.25