Assay Detail
Functional
CHEMBL5628813
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Synergistic antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs in presence vorinostat by CellTiterGlo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.46 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5631242 | — | — | 1 | 8.52 |
| CHEMBL4077071 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5631242 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4077071 | — | IC50 | = | 4.0 | nM | 8.40 |