Assay Detail
Binding
CHEMBL5628873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) using FTS as substrate preincubated for 10 mins followed by substrate addition measured after 1 min
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.35 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3693786 | CITARINOSTAT | 2.0 | 1 | 7.46 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3693786 | CITARINOSTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 58.0 | nM | 7.24 |