Assay Detail
Functional
CHEMBL5629508
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Anticancer activity against human A549 cells harboring KRAS mutant assessed as inhibition of cell growth
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.23 |
| CHEMBL5632436 | — | — | 1 | 5.54 |
| CHEMBL5632112 | — | — | 1 | 4.84 |
| CHEMBL5200160 | — | — | 1 | 4.71 |
| CHEMBL5181237 | — | — | 1 | 4.69 |
| CHEMBL5633661 | — | — | 1 | 4.58 |
| CHEMBL5633878 | — | — | 1 | - |
| CHEMBL1421 | DASATINIB ANHYDROUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5632436 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL5632112 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5200160 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL5181237 | — | IC50 | = | 20380.0 | nM | 4.69 |
| CHEMBL5633661 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL5633878 | — | IC50 | - | — | - | |
| CHEMBL1421 | DASATINIB ANHYDROUS | IC50 | - | — | - |