Assay Detail
Binding
CHEMBL5629584
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3H-SB-674042 from human Ox1R expressed in CHO cell membranes by liquid scintillation counting method
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.93 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083659 | SUVOREXANT | 4.0 | 1 | 9.17 |
| CHEMBL3958101 | CVN-766 | 1.0 | 1 | 8.14 |
| CHEMBL3932722 | — | — | 2 | 7.74 |
| CHEMBL3954899 | — | — | 1 | 7.68 |
| CHEMBL3957941 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083659 | SUVOREXANT | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL3958101 | CVN-766 | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL3932722 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL3932722 | — | Ki | = | 18.2 | nM | 7.74 |
| CHEMBL3954899 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL3957941 | — | Ki | = | 81.28 | nM | 7.09 |