Assay Detail
Toxicity
CHEMBL5629612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.04 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5631765 | — | — | 1 | 5.62 |
| CHEMBL5631499 | — | — | 1 | 4.89 |
| CHEMBL5633664 | — | — | 1 | 4.62 |
| CHEMBL5632134 | — | — | 1 | - |
| CHEMBL5631688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5631765 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5631499 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5633664 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5632134 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL5631688 | — | IC50 | > | 30000.0 | nM | - |