Assay Detail
Functional
CHEMBL5629638
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Inhibition of necroptosis in human U-937 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.99 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 8.23 |
| CHEMBL5632371 | — | — | 1 | 7.95 |
| CHEMBL5632067 | — | — | 1 | 7.44 |
| CHEMBL5633027 | — | — | 1 | 7.24 |
| CHEMBL5632839 | — | — | 1 | 7.21 |
| CHEMBL5633468 | — | — | 1 | 7.20 |
| CHEMBL5632090 | — | — | 1 | 7.10 |
| CHEMBL5633836 | — | — | 1 | 6.83 |
| CHEMBL5632042 | — | — | 1 | 6.37 |
| CHEMBL5633109 | — | — | 1 | 6.25 |
| CHEMBL5633631 | — | — | 1 | 6.05 |
| CHEMBL5631547 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071864 | GSK2982772 | IC50 | = | 5.888 | nM | 8.23 |
| CHEMBL5632371 | — | IC50 | = | 11.22 | nM | 7.95 |
| CHEMBL5632067 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL5633027 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL5632839 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL5633468 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5632090 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL5633836 | — | IC50 | = | 147.91 | nM | 6.83 |
| CHEMBL5632042 | — | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL5633109 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL5633631 | — | IC50 | = | 891.25 | nM | 6.05 |
| CHEMBL5631547 | — | IC50 | = | 1096.48 | nM | 5.96 |