Assay Detail
Binding
CHEMBL5634331
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Inhibition of HIV-1 protease expressed in Escherichia coli incubated for 90 mins by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.44 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5646760 | — | — | 1 | 7.46 |
| CHEMBL22164 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5646760 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL22164 | — | Ki | = | 38.0 | nM | 7.42 |