Assay Detail
Binding
CHEMBL5634377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type N-terminal 6His-tagged human recombinant TRKB G639R expressed in baculovirus-infected Sf21 cells incubated for 60 mins in presence of ATP by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in the discovery of tropomyosin receptor kinases TRKs inhibitors: A mini review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.30 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 10.30 |
| CHEMBL4468886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL4468886 | — | IC50 | > | 8100.0 | nM | - |