Assay Detail
Binding
CHEMBL5634378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type N-terminal 6His-tagged human recombinant TRKC G623R mutant (506 to 829 residues) expressed in baculovirus-infected Sf21 cells incubated for 60 mins in presence of ATP by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in the discovery of tropomyosin receptor kinases TRKs inhibitors: A mini review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.80 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 10.00 |
| CHEMBL4468886 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4468886 | — | IC50 | = | 2500.0 | nM | 5.60 |