Assay Detail
Binding
CHEMBL5634589
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Inhibition of PRDX1 (unknown origin) in presence of cofactor A/cofactor B/NADPH incubated for 25 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.10 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5647448 | — | — | 1 | 6.79 |
| CHEMBL5647239 | — | — | 1 | 6.78 |
| CHEMBL5639299 | — | — | 1 | 6.62 |
| CHEMBL5647369 | — | — | 1 | 6.54 |
| CHEMBL5646554 | — | — | 1 | 6.32 |
| CHEMBL5639325 | — | — | 1 | 6.28 |
| CHEMBL5647003 | — | — | 1 | 6.01 |
| CHEMBL5647534 | — | — | 1 | 5.83 |
| CHEMBL5646385 | — | — | 1 | 5.81 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.79 |
| CHEMBL5647082 | — | — | 1 | 5.60 |
| CHEMBL4860684 | — | — | 1 | 4.83 |
| CHEMBL303697 | LIGUSTRAZINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5647448 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL5647239 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL5639299 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL5647369 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL5646554 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL5639325 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL5647003 | — | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL5647534 | — | IC50 | = | 1472.0 | nM | 5.83 |
| CHEMBL5646385 | — | IC50 | = | 1534.0 | nM | 5.81 |
| CHEMBL301982 | CELASTROL | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL5647082 | — | IC50 | = | 2488.0 | nM | 5.60 |
| CHEMBL4860684 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL303697 | LIGUSTRAZINE | IC50 | - | — | - |