Assay Detail
Binding
CHEMBL5634698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERK phosphorylation in human NCI-H358 cells incubated for 3 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H358 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.41 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648852 | — | — | 1 | 9.00 |
| CHEMBL4648671 | — | — | 1 | 8.00 |
| CHEMBL4594350 | ADAGRASIB | 4.0 | 1 | 7.85 |
| CHEMBL4456598 | — | — | 1 | 6.85 |
| CHEMBL4647242 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648852 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4648671 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4594350 | ADAGRASIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4456598 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4647242 | — | IC50 | = | 4400.0 | nM | 5.36 |