Assay Detail
Binding
CHEMBL5634709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERK phosphorylation in human MKN-1 cells by Western blot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MKN-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.97 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5209371 | — | — | 1 | 7.58 |
| CHEMBL5192659 | MRTX-0902 | 1.0 | 1 | 7.54 |
| CHEMBL5208088 | — | — | 1 | 7.13 |
| CHEMBL5174300 | — | — | 1 | 6.78 |
| CHEMBL5171096 | — | — | 1 | 6.71 |
| CHEMBL5206295 | — | — | 1 | 6.60 |
| CHEMBL5202863 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5209371 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5192659 | MRTX-0902 | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5208088 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5174300 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL5171096 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5206295 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL5202863 | — | IC50 | = | 378.0 | nM | 6.42 |