Assay Detail
Binding
CHEMBL5634723
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Inhibition of KRAS G12C mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.14 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396975 | — | — | 1 | 6.47 |
| CHEMBL5436457 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396975 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5436457 | — | IC50 | = | 1540.0 | nM | 5.81 |