Assay Detail
Binding
CHEMBL5634756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK7/Cyclin H/MAT1 (unknown origin) by ADP-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.81 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5632010 | — | — | 1 | 6.27 |
| CHEMBL5287796 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5632010 | — | IC50 | = | 536.0 | nM | 6.27 |
| CHEMBL5287796 | — | IC50 | = | 4524.0 | nM | 5.34 |