Assay Detail
Functional
CHEMBL5634919
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Anti-adipogenic activity in mouse 3T3-L1 cells assessed as lipid-lowering activity measured after 9 days by Oil Red O staining based microplate reader analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 3T3-L1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.82 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639170 | — | — | 1 | 7.35 |
| CHEMBL5402446 | — | — | 1 | 7.11 |
| CHEMBL5639890 | — | — | 1 | 7.05 |
| CHEMBL301982 | CELASTROL | — | 1 | 7.00 |
| CHEMBL5647575 | — | — | 1 | 6.97 |
| CHEMBL5641669 | — | — | 1 | 6.96 |
| CHEMBL5639940 | — | — | 1 | 6.90 |
| CHEMBL5639250 | — | — | 1 | 6.75 |
| CHEMBL5641657 | — | — | 1 | 6.65 |
| CHEMBL5646707 | — | — | 1 | 6.59 |
| CHEMBL5647509 | — | — | 1 | 6.53 |
| CHEMBL5647491 | — | — | 1 | 6.51 |
| CHEMBL5646393 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639170 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5402446 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5639890 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL301982 | CELASTROL | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL5647575 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5641669 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL5639940 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5639250 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5641657 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL5646707 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5647509 | — | EC50 | = | 295.0 | nM | 6.53 |
| CHEMBL5647491 | — | EC50 | = | 309.0 | nM | 6.51 |
| CHEMBL5646393 | — | EC50 | = | 509.0 | nM | 6.29 |