Assay Detail
Binding
CHEMBL5635642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IABN from human D3 receptor expressed in HEK cells measured after 60 mins by gamma counting method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of bitopic ligands based on fallypride and evaluation of their affinity and selectivity towards dopamine D<sub>2</sub> and D<sub>3</sub> receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 7.93 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5641844 | — | — | 1 | 8.85 |
| CHEMBL5646949 | — | — | 1 | 8.82 |
| CHEMBL5639281 | — | — | 1 | 8.77 |
| CHEMBL5647349 | — | — | 1 | 8.62 |
| CHEMBL5639796 | — | — | 1 | 8.60 |
| CHEMBL5641706 | — | — | 1 | 8.59 |
| CHEMBL5647367 | — | — | 1 | 8.54 |
| CHEMBL5639198 | — | — | 1 | 8.43 |
| CHEMBL5639697 | — | — | 1 | 8.40 |
| CHEMBL5647154 | — | — | 1 | 8.39 |
| CHEMBL5647611 | — | — | 1 | 8.38 |
| CHEMBL5641522 | — | — | 1 | 8.37 |
| CHEMBL5646461 | — | — | 1 | 8.33 |
| CHEMBL5647616 | — | — | 1 | 8.21 |
| CHEMBL5639881 | — | — | 1 | 8.21 |
| CHEMBL5646887 | — | — | 1 | 8.21 |
| CHEMBL5641575 | — | — | 1 | 8.14 |
| CHEMBL5646837 | — | — | 1 | 8.11 |
| CHEMBL5647189 | — | — | 1 | 8.08 |
| CHEMBL5647451 | — | — | 1 | 8.08 |
| CHEMBL5646972 | — | — | 1 | 8.02 |
| CHEMBL5647418 | — | — | 1 | 8.02 |
| CHEMBL5639716 | — | — | 1 | 7.97 |
| CHEMBL5647399 | — | — | 1 | 7.90 |
| CHEMBL5647346 | — | — | 1 | 7.89 |
| CHEMBL5639255 | — | — | 1 | 7.84 |
| CHEMBL5641883 | — | — | 1 | 7.82 |
| CHEMBL5639121 | — | — | 1 | 7.80 |
| CHEMBL5639786 | — | — | 1 | 7.62 |
| CHEMBL5646712 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5641844 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL5646949 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL5639281 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL5647349 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL5639796 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL5641706 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL5647367 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL5639198 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL5639697 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL5647154 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL5647611 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL5641522 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL5646461 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL5646887 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL5639881 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL5647616 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL5641575 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL5646837 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL5647189 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL5647451 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL5646972 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL5647418 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL5639716 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL5647399 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL5647346 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL5639255 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL5641883 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL5639121 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL5639786 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL5646712 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL5646389 | — | Ki | = | 587.0 | nM | 6.23 |
| CHEMBL5639676 | — | Ki | = | 1313.0 | nM | 5.88 |
| CHEMBL5639547 | — | Ki | = | 1953.0 | nM | 5.71 |
| CHEMBL5647307 | — | Ki | = | 6785.0 | nM | 5.17 |