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Assay Detail

CHEMBL5635976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles.
Lougiakis N, Sakalis N, Georgiou M, Marakos P, Pouli N, Skaltsounis AL, Mavrogonatou E, Pratsinis H, Kletsas D.
Eur J Med Chem (2023) 261 : 115804 -115804
PubMed 37729693 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.57 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5647194 1 7.00
CHEMBL5639782 1 6.85
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 6.84
CHEMBL5646529 1 6.46
CHEMBL5646681 1 6.39
CHEMBL5641808 1 6.19
CHEMBL5640027 1 6.09
CHEMBL5639150 1 5.64
CHEMBL5646415 1 5.61
CHEMBL5646607 1 5.48
CHEMBL5647505 1 5.36
CHEMBL5639993 1 5.01
CHEMBL5647428 1 4.99
CHEMBL5647015 1 4.94
CHEMBL5639220 1 4.89
CHEMBL5646779 1 4.87
CHEMBL5639345 1 4.61
CHEMBL5647563 1 4.39
CHEMBL5639942 1 4.13
CHEMBL5647022 1 -
CHEMBL5646649 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5647194 IC50 = 100.0 nM 7.00
CHEMBL5639782 IC50 = 140.0 nM 6.85
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 144.0 nM 6.84
CHEMBL5646529 IC50 = 350.0 nM 6.46
CHEMBL5646681 IC50 = 410.0 nM 6.39
CHEMBL5641808 IC50 = 640.0 nM 6.19
CHEMBL5640027 IC50 = 810.0 nM 6.09
CHEMBL5639150 IC50 = 2290.0 nM 5.64
CHEMBL5646415 IC50 = 2480.0 nM 5.61
CHEMBL5646607 IC50 = 3340.0 nM 5.48
CHEMBL5647505 IC50 = 4390.0 nM 5.36
CHEMBL5639993 IC50 = 9700.0 nM 5.01
CHEMBL5647428 IC50 = 10300.0 nM 4.99
CHEMBL5647015 IC50 = 11400.0 nM 4.94
CHEMBL5639220 IC50 = 12900.0 nM 4.89
CHEMBL5646779 IC50 = 13400.0 nM 4.87
CHEMBL5639345 IC50 = 24500.0 nM 4.61
CHEMBL5647563 IC50 = 40800.0 nM 4.39
CHEMBL5639942 IC50 = 73300.0 nM 4.13
CHEMBL5647022 IC50 > 100000.0 nM -
CHEMBL5646649 IC50 > 100000.0 nM -