Assay Detail
Binding
CHEMBL5636346
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Inhibition of human JNK1 in presence of ATP
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.60 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5647005 | — | — | 1 | 8.74 |
| CHEMBL5641916 | — | — | 1 | 8.46 |
| CHEMBL5641827 | — | — | 1 | 8.43 |
| CHEMBL5647475 | — | — | 1 | 8.17 |
| CHEMBL5646811 | — | — | 1 | 7.82 |
| CHEMBL7064 | — | — | 1 | 7.40 |
| CHEMBL5639098 | — | — | 1 | 7.36 |
| CHEMBL5641807 | — | — | 1 | 7.25 |
| CHEMBL5641873 | — | — | 1 | 7.09 |
| CHEMBL5639526 | — | — | 1 | 7.01 |
| CHEMBL5639253 | — | — | 1 | 6.85 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5647005 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL5641916 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5641827 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL5647475 | — | IC50 | = | 6.81 | nM | 8.17 |
| CHEMBL5646811 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL7064 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5639098 | — | IC50 | = | 43.8 | nM | 7.36 |
| CHEMBL5641807 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL5641873 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL5639526 | — | IC50 | = | 97.8 | nM | 7.01 |
| CHEMBL5639253 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 212.0 | nM | 6.67 |