Assay Detail
Functional
CHEMBL5636463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human CAL-62 cells harboring KRAS G12R mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-62 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of Son of Sevenless Homologue 1 (SOS1): Promising therapeutic treatment for KRAS-mutant cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.16 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5287923 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5287923 | — | IC50 | = | 6.97 | nM | 8.16 |