Assay Detail
Functional
CHEMBL5637073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.56 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5641793 | — | — | 1 | 5.80 |
| CHEMBL4525049 | — | — | 1 | 5.79 |
| CHEMBL5639431 | — | — | 1 | 5.78 |
| CHEMBL5647229 | — | — | 1 | 5.73 |
| CHEMBL5556372 | — | — | 1 | 5.64 |
| CHEMBL5641584 | — | — | 1 | 5.62 |
| CHEMBL5646985 | — | — | 1 | 5.62 |
| CHEMBL5639334 | — | — | 1 | 5.61 |
| CHEMBL5639389 | — | — | 1 | 5.57 |
| CHEMBL5639823 | — | — | 1 | 5.54 |
| CHEMBL5641653 | — | — | 1 | 5.48 |
| CHEMBL5647155 | — | — | 1 | 5.39 |
| CHEMBL5639874 | — | — | 1 | 5.36 |
| CHEMBL5639406 | — | — | 1 | 5.27 |
| CHEMBL5639813 | — | — | 1 | 5.25 |
| CHEMBL5639370 | — | — | 1 | - |
| CHEMBL5639820 | — | — | 1 | - |
| CHEMBL5647103 | — | — | 1 | - |
| CHEMBL5647225 | — | — | 1 | - |
| CHEMBL5639933 | — | — | 1 | - |
| CHEMBL5647598 | — | — | 1 | - |
| CHEMBL5647589 | — | — | 1 | - |
| CHEMBL5647226 | — | — | 1 | - |
| CHEMBL5647048 | — | — | 1 | - |
| CHEMBL5639731 | — | — | 1 | - |
| CHEMBL5647532 | — | — | 1 | - |
| CHEMBL5639681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5641793 | — | IC50 | = | 1578.0 | nM | 5.80 |
| CHEMBL4525049 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5639431 | — | IC50 | = | 1649.0 | nM | 5.78 |
| CHEMBL5647229 | — | IC50 | = | 1854.0 | nM | 5.73 |
| CHEMBL5556372 | — | IC50 | = | 2305.0 | nM | 5.64 |
| CHEMBL5641584 | — | IC50 | = | 2396.0 | nM | 5.62 |
| CHEMBL5646985 | — | IC50 | = | 2374.0 | nM | 5.62 |
| CHEMBL5639334 | — | IC50 | = | 2439.0 | nM | 5.61 |
| CHEMBL5639389 | — | IC50 | = | 2713.0 | nM | 5.57 |
| CHEMBL5639823 | — | IC50 | = | 2876.0 | nM | 5.54 |
| CHEMBL5641653 | — | IC50 | = | 3293.0 | nM | 5.48 |
| CHEMBL5647155 | — | IC50 | = | 4103.0 | nM | 5.39 |
| CHEMBL5639874 | — | IC50 | = | 4324.0 | nM | 5.36 |
| CHEMBL5639406 | — | IC50 | = | 5342.0 | nM | 5.27 |
| CHEMBL5639813 | — | IC50 | = | 5681.0 | nM | 5.25 |
| CHEMBL5639370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639820 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647226 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647048 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639731 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639681 | — | IC50 | > | 10000.0 | nM | - |