Assay Detail
Functional
CHEMBL5637580
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Antiplasmodial activity against erythrocytic stage of chloroquine, pyrimethamine and sulfadoxine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in parasite growth incubated for 72 hrs by SYBR green I fluorescence based spectrophotometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.92 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5646444 | — | — | 1 | 7.00 |
| CHEMBL5639596 | — | — | 1 | 6.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.10 |
| CHEMBL5639348 | — | — | 1 | 6.05 |
| CHEMBL5647138 | — | — | 1 | 5.96 |
| CHEMBL5641686 | — | — | 1 | 5.85 |
| CHEMBL5641867 | — | — | 1 | 5.85 |
| CHEMBL5639982 | — | — | 1 | 5.38 |
| CHEMBL1433 | DOXYCYCLINE ANHYDROUS | 4.0 | 1 | 5.30 |
| CHEMBL5639093 | — | — | 1 | 5.01 |
| CHEMBL5641821 | — | — | 1 | - |
| CHEMBL5647344 | — | — | 1 | - |
| CHEMBL5639413 | — | — | 1 | - |
| CHEMBL5641912 | — | — | 1 | - |
| CHEMBL5639392 | — | — | 1 | - |
| CHEMBL5639558 | — | — | 1 | - |
| CHEMBL5647059 | — | — | 1 | - |
| CHEMBL5639706 | — | — | 1 | - |
| CHEMBL5641835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5646444 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5639596 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5639348 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5647138 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5641686 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5641867 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5639982 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1433 | DOXYCYCLINE ANHYDROUS | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5639093 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5641821 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL5647344 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5639413 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5641912 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5639392 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL5639558 | — | EC50 | > | 31250.0 | nM | - |
| CHEMBL5647059 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL5639706 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL5641835 | — | EC50 | > | 10000.0 | nM | - |