Assay Detail
Binding
CHEMBL5637747
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FLT3 D835Y mutant (unknown origin) using peptide substrate incubated for for 30 mins by HTRF assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of benzimidazole-indazole derivatives as potent FLT3-tyrosine kinase domain mutant kinase inhibitors for acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.56 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5641673 | — | — | 1 | 10.21 |
| CHEMBL5639279 | — | — | 1 | 9.70 |
| CHEMBL5647669 | — | — | 1 | 9.64 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5641673 | — | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL5639279 | — | IC50 | = | 0.199 | nM | 9.70 |
| CHEMBL5647669 | — | IC50 | = | 0.227 | nM | 9.64 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 2.02 | nM | 8.70 |