Assay Detail
Binding
CHEMBL5638044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length recombinant human PDE6C using [3H]-cGMP as substrate incubated for 10 mins by SPA assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (CHEMBL3977) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.93 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5647232 | — | — | 1 | 7.05 |
| CHEMBL5639763 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5647232 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5639763 | — | IC50 | = | 160.0 | nM | 6.80 |