Assay Detail
Binding
CHEMBL5638243
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Inhibition of HDAC2 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hrs followed by substrate addition and measured after 2 hrs by spectrophotometer based fluorometric assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.51 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639904 | — | — | 1 | 6.89 |
| CHEMBL5647223 | — | — | 1 | 6.77 |
| CHEMBL5639636 | — | — | 1 | 6.62 |
| CHEMBL5639136 | — | — | 1 | 6.61 |
| CHEMBL5646494 | — | — | 1 | 6.53 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 6.44 |
| CHEMBL5639135 | — | — | 1 | 6.35 |
| CHEMBL5641600 | — | — | 1 | 6.34 |
| CHEMBL5639599 | — | — | 1 | 6.31 |
| CHEMBL5641748 | — | — | 1 | 6.22 |
| CHEMBL5639202 | — | — | 1 | - |
| CHEMBL5639918 | — | — | 1 | - |
| CHEMBL5646792 | — | — | 1 | - |
| CHEMBL5639397 | — | — | 1 | - |
| CHEMBL5647361 | — | — | 1 | - |
| CHEMBL5646831 | — | — | 1 | - |
| CHEMBL5639116 | — | — | 1 | - |
| CHEMBL5639808 | — | — | 1 | - |
| CHEMBL5647285 | — | — | 1 | - |
| CHEMBL5639572 | — | — | 1 | - |
| CHEMBL5646723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639904 | — | IC50 | = | 127.8 | nM | 6.89 |
| CHEMBL5647223 | — | IC50 | = | 168.2 | nM | 6.77 |
| CHEMBL5639636 | — | IC50 | = | 240.7 | nM | 6.62 |
| CHEMBL5639136 | — | IC50 | = | 247.2 | nM | 6.61 |
| CHEMBL5646494 | — | IC50 | = | 295.3 | nM | 6.53 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 363.9 | nM | 6.44 |
| CHEMBL5639135 | — | IC50 | = | 443.3 | nM | 6.35 |
| CHEMBL5641600 | — | IC50 | = | 459.1 | nM | 6.34 |
| CHEMBL5639599 | — | IC50 | = | 489.8 | nM | 6.31 |
| CHEMBL5641748 | — | IC50 | = | 602.2 | nM | 6.22 |
| CHEMBL5639202 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639918 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5646792 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647361 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5646831 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639116 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639808 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5647285 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5639572 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5646723 | — | IC50 | > | 10000.0 | nM | - |