Assay Detail
Functional
CHEMBL5638255
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Antiproliferative activity against human MM1.S cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.45 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639135 | — | — | 1 | 5.54 |
| CHEMBL5639918 | — | — | 1 | 5.48 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639135 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5639918 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 4700.0 | nM | 5.33 |