Assay Detail
Binding
CHEMBL5638932
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Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated for 15 mins followed by enzyme addition and measured after 20 mins by fluorescence microplate reader analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.06 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 7.75 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | 7.38 |
| CHEMBL5647365 | — | — | 1 | 6.40 |
| CHEMBL5646854 | — | — | 1 | 5.99 |
| CHEMBL5639837 | — | — | 1 | 5.96 |
| CHEMBL5646671 | — | — | 1 | 5.63 |
| CHEMBL5646700 | — | — | 1 | 5.28 |
| CHEMBL5639741 | — | — | 1 | 5.08 |
| CHEMBL5646540 | — | — | 1 | 5.04 |
| CHEMBL5639156 | — | — | 1 | 5.00 |
| CHEMBL5647252 | — | — | 1 | 4.92 |
| CHEMBL5639969 | — | — | 1 | 4.85 |
| CHEMBL5647379 | — | — | 1 | 4.62 |
| CHEMBL5647105 | — | — | 1 | 4.46 |
| CHEMBL5639910 | — | — | 1 | 4.43 |
| CHEMBL5647322 | — | — | 1 | 4.43 |
| CHEMBL5647192 | — | — | 1 | 4.42 |
| CHEMBL5641857 | — | — | 1 | 4.24 |
| CHEMBL5647270 | — | — | 1 | 4.18 |
| CHEMBL5647577 | — | — | 1 | 4.17 |
| CHEMBL5641820 | — | — | 1 | 4.10 |
| CHEMBL5639628 | — | — | 1 | 4.09 |
| CHEMBL5639688 | — | — | 1 | 4.01 |
| CHEMBL5647096 | — | — | 1 | - |
| CHEMBL5646989 | — | — | 1 | - |
| CHEMBL5639776 | — | — | 1 | - |
| CHEMBL5639166 | — | — | 1 | - |
| CHEMBL5639356 | — | — | 1 | - |
| CHEMBL5641666 | — | — | 1 | - |
| CHEMBL8663 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL269538 | HARMINE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5647365 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL5646854 | — | IC50 | = | 1035.0 | nM | 5.99 |
| CHEMBL5639837 | — | IC50 | = | 1096.0 | nM | 5.96 |
| CHEMBL5646671 | — | IC50 | = | 2339.0 | nM | 5.63 |
| CHEMBL5646700 | — | IC50 | = | 5233.0 | nM | 5.28 |
| CHEMBL5639741 | — | IC50 | = | 8231.0 | nM | 5.08 |
| CHEMBL5646540 | — | IC50 | = | 9144.0 | nM | 5.04 |
| CHEMBL5639156 | — | IC50 | = | 9891.0 | nM | 5.00 |
| CHEMBL5647252 | — | IC50 | = | 12040.0 | nM | 4.92 |
| CHEMBL5639969 | — | IC50 | = | 14260.0 | nM | 4.85 |
| CHEMBL5647379 | — | IC50 | = | 23850.0 | nM | 4.62 |
| CHEMBL5647105 | — | IC50 | = | 34630.0 | nM | 4.46 |
| CHEMBL5647322 | — | IC50 | = | 36860.0 | nM | 4.43 |
| CHEMBL5639910 | — | IC50 | = | 36750.0 | nM | 4.43 |
| CHEMBL5647192 | — | IC50 | = | 38130.0 | nM | 4.42 |
| CHEMBL5641857 | — | IC50 | = | 57220.0 | nM | 4.24 |
| CHEMBL5647270 | — | IC50 | = | 65980.0 | nM | 4.18 |
| CHEMBL5647577 | — | IC50 | = | 67270.0 | nM | 4.17 |
| CHEMBL5641820 | — | IC50 | = | 79890.0 | nM | 4.10 |
| CHEMBL5639628 | — | IC50 | = | 80920.0 | nM | 4.09 |
| CHEMBL5639688 | — | IC50 | = | 96750.0 | nM | 4.01 |
| CHEMBL5639834 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646951 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646639 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646711 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646936 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639274 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639289 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL396778 | SAFINAMIDE | IC50 | - | — | - | |
| CHEMBL8663 | — | IC50 | - | — | - | |
| CHEMBL5641666 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5639776 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5646989 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5647096 | — | IC50 | > | 100000.0 | nM | - |