Assay Detail
Functional
CHEMBL5638948
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Antiproliferative activity against human JeKo-1 cells assessed as reduction in cell viability by Cell-Titer Glo luminescent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JeKo-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Exatecan-Derived Topoisomerase-1 Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.84 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5641687 | — | — | 1 | 8.92 |
| CHEMBL5647672 | — | — | 1 | 8.85 |
| CHEMBL5647124 | — | — | 1 | 8.85 |
| CHEMBL5646688 | — | — | 1 | 8.82 |
| CHEMBL5646395 | — | — | 1 | 8.80 |
| CHEMBL5646508 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5641687 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5647672 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5647124 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5646688 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5646395 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5646508 | — | EC50 | = | 1.6 | nM | 8.80 |