Assay Detail
Binding
CHEMBL5648058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of KDM6B (unknown origin) using biotinylated H3K27me3 peptide as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins in presence of 2-oxoglutarate/Fe2+/L-ascorbic acid by AlphaScreen assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of demethylases by GSK-J1/J4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.22 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188597 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188597 | — | IC50 | = | 60.0 | nM | 7.22 |