Assay Detail
Binding
CHEMBL5648074
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Inhibition of epitope-tagged KDM5B (1 to 752 residues)(unknown origin) transfected in human U2OS cells using H3K4me2 peptide as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of demethylases by GSK-J1/J4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183531 | — | — | 1 | 5.51 |
| CHEMBL3188597 | — | — | 1 | - |
| CHEMBL4303308 | — | — | 1 | - |
| CHEMBL4786329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183531 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3188597 | — | IC50 | - | — | - | |
| CHEMBL4303308 | — | IC50 | - | — | - | |
| CHEMBL4786329 | — | IC50 | > | 10000.0 | nM | - |