Assay Detail
Functional
CHEMBL5648233
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Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 5 days
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular basis underlying resistance to Mps1/TTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.08 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757879 | — | — | 1 | 7.69 |
| CHEMBL2047943 | — | — | 1 | 6.98 |
| CHEMBL1236095 | — | — | 1 | 6.82 |
| CHEMBL188343 | REVERSINE | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757879 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL2047943 | — | IC50 | = | 105.6 | nM | 6.98 |
| CHEMBL1236095 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL188343 | REVERSINE | IC50 | = | 154.1 | nM | 6.81 |