Assay Detail
Functional
CHEMBL5648256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of colony formation in human HeLa cells harboring Mps1 I598F mutant assessed as cell survival incubated for 5 days by crystal violet staining based colony formation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular basis underlying resistance to Mps1/TTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.06 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757879 | — | — | 1 | 7.05 |
| CHEMBL188343 | REVERSINE | — | 1 | 6.37 |
| CHEMBL2047943 | — | — | 1 | 6.33 |
| CHEMBL1236095 | — | — | 1 | 5.88 |
| CHEMBL2140523 | — | — | 1 | 5.42 |
| CHEMBL4474534 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757879 | — | IC50 | = | 89.2 | nM | 7.05 |
| CHEMBL188343 | REVERSINE | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL2047943 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL1236095 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL2140523 | — | IC50 | = | 3847.0 | nM | 5.42 |
| CHEMBL4474534 | — | IC50 | = | 4793.0 | nM | 5.32 |