Assay Detail
Binding
CHEMBL5650085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 6His-(Tev)-G-SUV420H1 (69 to 335 residues) using Biotin-tagged H4K20me1 and [3H-SAM] as substrate incubated for 2 hrs by scintillation proximity assay
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase KMT5B (CHEMBL2321645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.67 | 7.60 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521971 | — | — | 2 | 7.60 |
| CHEMBL5653590 | — | — | 1 | 6.23 |
| CHEMBL1288796 | — | — | 1 | 5.23 |
| CHEMBL5653592 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521971 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4521971 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5653590 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1288796 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5653592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5653592 | — | Inhibition | - | % | - |