Assay Detail
Binding
CHEMBL5650783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nano Luc-fused full length C-terminal EPHA3 (unknown origin) expressed in HEK293T cells using NanoGlo as substrate incubated for 2 hrs in presence of tracer by NanoBRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.78 | 9.52 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752910 | — | — | 1 | 9.52 |
| CHEMBL1421 | DASATINIB ANHYDROUS | 4.0 | 1 | 9.52 |
| CHEMBL5653589 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752910 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1421 | DASATINIB ANHYDROUS | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5653589 | — | IC50 | = | 50.0 | nM | 7.30 |