Assay Detail
Binding
CHEMBL5653931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PKA (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.65 | 6.30 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000365 |
| EFO_ID | EFO_ID | - | — | MONDO:0018177 |
| EFO_TERM | EFO_TERM | - | — | colorectal adenocarcinoma |
| EFO_TERM | EFO_TERM | - | — | glioblastoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124072 | — | — | 1 | 6.30 |
| CHEMBL270875 | — | — | 1 | 6.30 |
| CHEMBL403771 | — | — | 1 | 5.92 |
| CHEMBL5661941 | — | — | 1 | 5.82 |
| CHEMBL266487 | RO-316233 | — | 1 | 5.70 |
| CHEMBL7463 | GF-109203 | — | 1 | 5.70 |
| CHEMBL5661886 | — | — | 1 | 5.70 |
| CHEMBL5661906 | — | — | 1 | 5.60 |
| CHEMBL5661881 | — | — | 1 | 5.52 |
| CHEMBL268769 | — | — | 1 | 5.46 |
| CHEMBL446199 | — | — | 1 | 5.36 |
| CHEMBL5661916 | — | — | 1 | 5.35 |
| CHEMBL5661889 | — | — | 1 | 5.22 |
| CHEMBL5661912 | — | — | 1 | 5.18 |
| CHEMBL5661835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124072 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL270875 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL403771 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5661941 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL266487 | RO-316233 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7463 | GF-109203 | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5661886 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5661906 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5661881 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL268769 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL446199 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5661916 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5661889 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5661912 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5661835 | — | IC50 | > | 10000.0 | nM | - |