Assay Detail
Binding
CHEMBL5653932
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Inhibition of Phosphorylase kinase in rabbit muscle tissue in presence of [p32-gamma]-ATP measured after 10 mins by scintillation counter analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.04 | 7.32 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000365 |
| EFO_ID | EFO_ID | - | — | MONDO:0018177 |
| EFO_TERM | EFO_TERM | - | — | colorectal adenocarcinoma |
| EFO_TERM | EFO_TERM | - | — | glioblastoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.32 |
| CHEMBL270875 | — | — | 1 | 6.75 |
| CHEMBL124072 | — | — | 1 | 6.70 |
| CHEMBL403771 | — | — | 1 | 6.40 |
| CHEMBL7463 | GF-109203 | — | 1 | 6.16 |
| CHEMBL5661886 | — | — | 1 | 6.12 |
| CHEMBL5661906 | — | — | 1 | 5.92 |
| CHEMBL268769 | — | — | 1 | 5.77 |
| CHEMBL5661889 | — | — | 1 | 5.75 |
| CHEMBL5661912 | — | — | 1 | 5.70 |
| CHEMBL5661881 | — | — | 1 | 5.70 |
| CHEMBL5661835 | — | — | 1 | 5.56 |
| CHEMBL266487 | RO-316233 | — | 1 | 5.50 |
| CHEMBL446199 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL270875 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL124072 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL403771 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL7463 | GF-109203 | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5661886 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5661906 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL268769 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5661889 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5661912 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5661881 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5661835 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL266487 | RO-316233 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL446199 | — | IC50 | = | 5700.0 | nM | 5.24 |