Assay Detail
Binding
CHEMBL5653933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain PKC in presence of [p32-gamma]-ATP measured after 10 mins by scintillation counter analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.81 | 8.30 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000365 |
| EFO_ID | EFO_ID | - | — | MONDO:0018177 |
| EFO_TERM | EFO_TERM | - | — | colorectal adenocarcinoma |
| EFO_TERM | EFO_TERM | - | — | glioblastoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403771 | — | — | 1 | 8.30 |
| CHEMBL7463 | GF-109203 | — | 1 | 8.00 |
| CHEMBL5661886 | — | — | 1 | 7.89 |
| CHEMBL270875 | — | — | 1 | 7.58 |
| CHEMBL268769 | — | — | 1 | 7.40 |
| CHEMBL5661906 | — | — | 1 | 7.35 |
| CHEMBL446199 | — | — | 1 | 7.28 |
| CHEMBL5661881 | — | — | 1 | 7.16 |
| CHEMBL5661912 | — | — | 1 | 7.10 |
| CHEMBL266487 | RO-316233 | — | 1 | 7.00 |
| CHEMBL5661889 | — | — | 1 | 7.00 |
| CHEMBL5661916 | — | — | 1 | 6.70 |
| CHEMBL495845 | ARCYRIARUBIN B | — | 1 | 6.70 |
| CHEMBL5661941 | — | — | 1 | 6.70 |
| CHEMBL124072 | — | — | 1 | 6.58 |
| CHEMBL298818 | — | — | 1 | 5.70 |
| CHEMBL5661835 | — | — | 1 | 5.56 |
| CHEMBL301741 | — | — | 1 | 5.00 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 4.40 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | - |
| CHEMBL5661830 | — | — | 1 | - |
| CHEMBL5661877 | — | — | 1 | - |
| CHEMBL294450 | — | — | 1 | - |
| CHEMBL291725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403771 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL7463 | GF-109203 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5661886 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL270875 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL268769 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5661906 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL446199 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5661881 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5661912 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL266487 | RO-316233 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5661889 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5661916 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL495845 | ARCYRIARUBIN B | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5661941 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL124072 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL298818 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5661835 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL301741 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | > | 25000.0 | nM | - |
| CHEMBL5661830 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5661877 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL294450 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL291725 | — | IC50 | > | 50000.0 | nM | - |