Assay Detail
Binding
CHEMBL5653978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PDBu from PKC in bovine brain assessed as inhibition constant incubated for 70 mins by liquid scintillation counter based dixon plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 7.85 | 7.85 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000365 |
| EFO_ID | EFO_ID | - | — | MONDO:0018177 |
| EFO_TERM | EFO_TERM | - | — | colorectal adenocarcinoma |
| EFO_TERM | EFO_TERM | - | — | glioblastoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7463 | GF-109203 | Ki | = | 14.0 | nM | 7.85 |