Assay Detail
Toxicity
CHEMBL5654076
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Inhibition of recombinant human HDAC1 using fluorogenic RHKKAc peptide as substrate by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.41 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511749 | — | — | 1 | 7.15 |
| CHEMBL3675752 | — | — | 1 | 6.69 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.85 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.32 |
| CHEMBL5661880 | — | — | 1 | 5.29 |
| CHEMBL3675747 | — | — | 1 | 5.07 |
| CHEMBL2170166 | — | — | 1 | 4.96 |
| CHEMBL3675751 | — | — | 1 | 4.89 |
| CHEMBL1290142 | — | — | 1 | 4.85 |
| CHEMBL5661899 | — | — | 1 | 4.79 |
| CHEMBL5661883 | — | — | 1 | 4.60 |
| CHEMBL5661837 | — | — | 1 | - |
| CHEMBL3675750 | — | — | 1 | - |
| CHEMBL3675753 | — | — | 1 | - |
| CHEMBL3675754 | — | — | 1 | - |
| CHEMBL3675755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511749 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3675752 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL356769 | TUBACIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL5661880 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL3675747 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2170166 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3675751 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1290142 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5661899 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL5661883 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL5661837 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3675750 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3675753 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3675754 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3675755 | — | IC50 | > | 30000.0 | nM | - |