Assay Detail
Toxicity
CHEMBL5654084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC8 using fluorogenic RHKAcKAc peptide as substrate by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.99 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5661899 | — | — | 1 | 6.07 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5661899 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL356769 | TUBACIN | IC50 | = | 1270.0 | nM | 5.90 |