Assay Detail
Functional
CHEMBL5654576
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Downregulation of H3K79 methylation in human A-431 cells incubated for 3 to 4 days by microscopy based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.58 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087498 | — | — | 1 | 8.58 |
| CHEMBL2169919 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087498 | — | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL2169919 | — | IC50 | = | 264.0 | nM | 6.58 |