Assay Detail
Binding
CHEMBL5654715
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PAK2 (unknown origin) by Z'-LYTE functional assay
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PAK 2 (CHEMBL4487) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.40 | 7.40 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0010383 |
| EFO_TERM | EFO_TERM | - | — | fragile x syndrome |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609326 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609326 | — | IC50 | = | 39.5 | nM | 7.40 |