Assay Detail
Binding
CHEMBL5657202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 21 residues) as substrate and SAM as cofactor preincubated for 20 mins followed by substrate addition and measured after 120 mins by LC-MS analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.18 | 7.18 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0008116 |
| EFO_ID | EFO_ID | - | — | EFO:0001645 |
| EFO_TERM | EFO_TERM | - | — | oculopharyngeal muscular dystrophy |
| EFO_TERM | EFO_TERM | - | — | coronary artery disease |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072005 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072005 | — | IC50 | = | 66.0 | nM | 7.18 |