Assay Detail
Binding
CHEMBL5657204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PRMT3 (unknown origin) assessed as dissociation constant by ITC analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.28 | 7.28 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0008116 |
| EFO_ID | EFO_ID | - | — | EFO:0001645 |
| EFO_TERM | EFO_TERM | - | — | oculopharyngeal muscular dystrophy |
| EFO_TERM | EFO_TERM | - | — | coronary artery disease |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072005 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072005 | — | Kd | = | 53.0 | nM | 7.28 |